Contribution of increased mitochondrial
โ
Aaron M. Byrne; John J. Lemasters; Anna-Liisa Nieminen
๐
Article
๐
1999
๐
John Wiley and Sons
๐
English
โ 356 KB
Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc