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The Continuous-Flow Synthesis of Ibuprofen

✍ Scribed by Andrew R. Bogdan; Sarah L. Poe; Daniel C. Kubis; Steven J. Broadwater; D. Tyler McQuade

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
390 KB
Volume
121
Category
Article
ISSN
0044-8249

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The Continuous-Flow Synthesis of Ibuprof
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## Abstract A two‐step continuous‐flow protocol for the synthesis of 2‐amino‐4′‐chlorobiphenyl, a key intermediate for the industrial preparation of the fungicide Boscalid^®^ is described. Initial tetrakis(triphenylphosphine)palladium‐catalyzed high‐temperature Suzuki–Miyaura cross‐coupling of 1‐ch