Despite extensive investigations, the cause of liver injury in 14% of patients with acute liver failure remains unknown (indeterminate). In a pilot study using a novel assay, highly specific acetaminophen-cysteine adducts were detected in 7 of 36 indeterminate patients (19%). To extend these observa
✦ LIBER ✦
The Continuing Challenge of “Indeterminate” Acute Liver Failure in Children
✍ Scribed by Dennis D. Black
- Book ID
- 113745531
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 67 KB
- Volume
- 155
- Category
- Article
- ISSN
- 1097-6833
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## Key Points 1. The etiology of acute liver failure in children differs from that in adults, with metabolic conditions being commoner in Europe and North America and hepatitis A being the commonest cause in Asia and South America. 2. Encephalopathy usually is a late feature and is not essential fo