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The construction of defective interfering rubella virus particles

✍ Scribed by G. Terry; P. Londesborough; L. Ho

Publisher
Springer Vienna
Year
2000
Tongue
English
Weight
99 KB
Volume
145
Category
Article
ISSN
1432-8798

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Defective-interfering (DI) viruses arise spontaneously by deletion mutations. The shortened genomes of the DI particles cannot replicate unless they coinfect a cell with a wild-type virus. Upon coinfection, the DI genome replicates more quickly and outcompetes the wild type. The coinfected cell prod