Atisine (l), an alkaloid of Aconitum heterophyllum Wall, is usually isolated' as the salt, atisinium chloride (2), and can be regenerated from this salt by treatment with strong base. Atisine is a very strong base (pKa 12.8) that may be isamerized easily to isoatisine (3) (pKa 10.3) by refluxing in
The conformational analysis of the E and F rings of atisine, veatchine, and related alkaloids. The existence of C-20 epimers
β Scribed by Pelletier, S. William; Mody, Naresh V.
- Book ID
- 127198541
- Publisher
- American Chemical Society
- Year
- 1977
- Tongue
- English
- Weight
- 381 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
The recent articles by Pelletier 2B3 on the relative stereochemistry of the diterpene alkaloids of the veatchineatisine class4 prompt us to record some of our own results in this field. As will be shown below, our investigations establish the absolute configuration of the C/D ring juncture and by in
One phase of any successful totally synthetic approach to the construction of the diterpenoid alkaloids atisine (l)l and garryfoline (2)1'2 must be the elaboration of the C/D bicyclic ring system. While a method for the construction of such ring systems would be premature without the availability of