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The configurational dependence of binding free energies: A Poisson–Boltzmann study of Neuraminidase inhibitors

✍ Scribed by Christopher J. Woods; Michael A. King; Jonathan W. Essex

Book ID
110260003
Publisher
Springer Netherlands
Year
2001
Tongue
English
Weight
220 KB
Volume
15
Category
Article
ISSN
0920-654X

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## Abstract Zinc endopeptidase thermolysin can be inhibited by a series of phosphorus‐containing peptide analogues, Cbz‐Gly‐__ψ__(PO~2~)‐X‐Leu‐Y‐R (ZG^P^(X)L(Y)R), where X = NH, O, or CH~2~; Y = NH or O; and R = Leu, Ala, Gly, Phe, H, or CH~3~. The affinity correlation as well as an X‐ray crystallo