The tautomerism of Omeprazole in solutio
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Rosa M. Claramunt; Concepción López; Ibon Alkorta; José Elguero; Rong Yang; Stev
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Article
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2004
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John Wiley and Sons
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English
⚖ 90 KB
👁 2 views
## Abstract The tautomerism of 5(6)‐methoxy‐2‐{[(4‐methoxy‐3,5‐dimethyl‐2‐pyridinyl)methyl] sulfinyl}‐1__H__‐benzimidazole (omeprazole) was determined in solution, __K__~__T__~ = 0.59 in THF at 195 K, in favor of the 6‐methoxy tautomer. The assignment of the signals was made by comparison with its