✦ LIBER ✦

The complexity in regulating the expression of tenascins

✍ Scribed by Ruth Chiquet-Ehrismann; Carmen Hagios; Susanne Schenk

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Volume: 17
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950171009

No coin nor oath required. For personal study only.

✦ Synopsis

The tenascins are a growing family of extracellular matrix proteins of typical multidomain structure. The prototype to be discovered was tenascin-C. It shows a highly regulated expression pattern during embryonic development and is often transiently associated with morphogenetic tissue interactions during organogenesis. In the adult organism reexpression of tenascin-C occurs in tumors and many other pathological conditions. Tenascin-C expression can be regulated by many different growth factors and hormones. Furthermore, mechanical strain exerted by fibroblasts seems to induce the expression of tenascin-C. This could represent a mechanism of translating mechanical forces into protein patterns, a step of potential relevance in the organization of embryogenesis. Tenascin-C as well as tenascin-R are believed to counteract the cell adhesion and spreading activity of fibronectin, thereby facilitating cell Accepted move men t .

📜 SIMILAR VOLUMES

Regulation of tenascin expression in bon

Regulation of tenascin expression in bone

✍ Jessica M. Morgan; Alice Wong; Clare E. Yellowley; Damian C. Genetos 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

## Abstract Tenascins regulate cell interaction with the surrounding pericellular matrix. Within bone, tenascins C and W influence osteoblast adhesion and differentiation, although little is known about the regulation of tenascin expression. In this study we examined the effect of osteogenic differ

Tenascin-C regulates angiogenesis in tum

Tenascin-C regulates angiogenesis in tumor through the regulation of vascular endothelial growth factor expression

✍ Keiichiro Tanaka; Noriko Hiraiwa; Hisashi Hashimoto; Yoji Yamazaki; Moriaki Kusa 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 854 KB

## Abstract In order to verify whether tenascin‐C (TN‐C) is involved in angiogenesis as an extracellular signal molecule during tumorigenesis, cancerous cell transplantation experiments and coculture experiments were carried out, focusing on the regulation of vascular endothelial growth factor (VEG

Limiting the complexity of limit sets in

Limiting the complexity of limit sets in self-regulating systems

✍ Geoffrey Butler; Rudolf Schmid; Paul Waltman 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 280 KB

Expression of tenascin in gastric carcin

Expression of tenascin in gastric carcinoma

✍ K. Ilunga; Dr K. Iriyama 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 486 KB

Tenascin C and tenascin R similarly prev

Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway

✍ Tim Czopka; Alexander Von Holst; Gudula Schmidt; Charles Ffrench-Constant; Andre 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 764 KB

## Abstract Membrane formation and the initiation of myelin gene expression are hallmarks of the differentiation of oligodendrocytes from their precursors. Here, we compared the roles of the two related extracellular matrix (ECM) glycoproteins Tenascin C (Tnc) and Tenascin R (Tnr) in oligodendrocyt

Detection of tenascin-C in the nervous s

Detection of tenascin-C in the nervous system of the tenascin-C mutant mouse

✍ N. Mitrovic; M. Schachner 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 910 KB

We have investigated the expression of tenascin-C (TN-C) in the somatosensory cortex of early postnatal mutant mice in which lac2 was reported to be expressed in place of tenascin (Saga et al.: Genes Dev 6:1821-1831, 1992). At both the mRNA and protein levels, TN-C was detected at levels lower in th