By using in situ hybridization in the golden hamster brain, we have found that vgf mRNA levels are induced as a response to light stimulation in the suprachiasmatic nuclei (SCN), the site of the mammalian circadian pacemaker. The induction exhibits delayed kinetics relative to known light-induced im
✦ LIBER ✦
The complex regulation of ferredoxin/thioredoxin-related genes by light and the circadian clock
✍ Scribed by Stéphane D. Lemaire; Mariana Stein; Emmanuelle Issakidis-Bourguet; Eliane Keryer; Vanina Benoit; Bernard Pineau; Catherine Gérard-Hirne; Myroslawa Miginiac-Maslow; Jean-Pierre Jacquot
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 234 KB
- Volume
- 209
- Category
- Article
- ISSN
- 0032-0935
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## Abstract Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. We and others demonstrated that treatment of cortical neurons with the proteasomal inhibitor lactacystin lea