The distribution of the antidepressant drug nortriptyline (NT) and its main metabolite E-10-hydroxy-nortriptyline (E-10-OH-NT) across the blood-brain barrier was considered in relation to inhibition of the multidrug transporter P-glycoprotein (P-gp). Rats received NT in doses of 25 mg/kg orally, 10
β¦ LIBER β¦
The complex binding of tricyclic antidepressants to rat brain: The case of nortriptyline
β Scribed by Anat Biegon
- Book ID
- 118869217
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 725 KB
- Volume
- 321
- Category
- Article
- ISSN
- 0006-8993
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Eight patients with major depression but otherwise healthy underwent radionuclide cardiography before and during nortriptyline treatment. The second examination was performed when the nortriptyline plasma concentration was within the therapeutic range (60-150 micrograms X l-1). Heart rate, arterial