The Complete CDS of the Prion Protein (PRNP) Gene of African Lion (Panthera leo)
β Scribed by Andrzej Maj; Garth M. Spellman; Shane K. Sarver
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 347 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0920-8569
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Mutation of the human prion protein gene (PRNP) open reading frame (ORF) accounts for almost all reported familial concurrence of prion disease. The more common mutations globally: octapeptide repeat insertions, P102L, D178N, E200K, and V210I have occurred in large multigenerational pedigrees and di
## Summary Twentyβfour microsatellite sites with at least three repeats were found in the bovine prion protein gene (__PRNP__) and 23 in the ovine __PRNP__ gene. Eight microsatellite sites were polymorphic in cattle and six in sheep with up to 10 alleles per site. In many cases allelic DNA fragment