The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-α-independent manner

Lipopolysaccharide increases microglial

Lipopolysaccharide increases microglial GLT-1 expression and glutamate uptake capacity in vitro by a mechanism dependent on TNF-α

✍ Mikael Persson; Mona Brantefjord; Elisabeth Hansson; Lars Rönnbäck 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB

## Abstract This study investigates the effect of microglial activation on microglial glutamate transporters in vitro. Stimuli known to activate microglia and/or to be associated with pathological conditions with an impaired astroglial glutamate uptake were compared. Morphological changes and marke