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The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

✍ Scribed by Shilatifard, Ali

Book ID
111918447
Publisher
Annual Reviews
Year
2012
Tongue
English
Weight
852 KB
Volume
81
Category
Article
ISSN
0066-4154

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## Background In the mouse zygote the paternal genome undergoes dramatic structural and epigenetic changes. Chromosomes are decondensed, protamines replaced by histones and DNA is rapidly and actively demethylated. The epigenetic asymmetry between parental genomes remains at least until the 2-cell