The active vitamin D metabolite 1,25-dihydroxyvitamin D3 [1,25-D3] is thought to promote many of its actions through interaction with a specific intracellular receptor. The discovery of such receptors in monocytes and activated lymphocytes has led investigators to evaluate the role of the hormone on
The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents
β Scribed by Chantal Mathieu; Luciano Adorini
- Book ID
- 117787916
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 202 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1471-4914
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## Abstract The active form of vitamin D~3~, 1,25(OH)~2~D~3~, is known, besides its classical effects on calcium and bone, for its pronounced immunomodulatory effects that are exerted both on the antigenβpresenting cell level as well as directly on the T lymphocyte level. In animal models, these im
In this communication we describe the synthesis of \(1 \alpha, 25\)-dihydroxyvitamin \(\mathrm{D}_{3}\) - \(3 \beta\)-bromoacetate \(\left[1,25(\mathrm{OH})_{2}-\mathrm{BE}\right]\), an analog of \(1 \alpha, 25\)-dihydroxyvitamin \(\mathrm{D}_{3}\left[1,25(\mathrm{OH})_{2} \mathrm{D}_{3}\right]\), a