The ComDarative Antispasmodic Activity of NMetGyl-3-Piperidyf Diphenylglycolate Methobromide (JB-340) and Atropine Sulfate**Department of Pharmacology, the University of Pittsburgh School of Pharmacy, Pittsburgh, Pa.
✍ Scribed by Buckley, J.P. ;Defeo, J.J. ;Reif, Edward C.
- Publisher
- Elsevier
- Year
- 1957
- Weight
- 269 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0095-9553
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✦ Synopsis
T h e antispasmodic activity of N-methyl-3-piperidyl diphenylglycolate methobromide (JB-340) was evaluated against atropine sulfate o n various segments of the normal and spastic gastrointestinal tract of cats and dogs under pentobarbital sodium anesthesia. JB-340,0.5 mg./Kg. I.V., exhibited a depressant activity equal to or greater than 0.2 mg./Kg. of atropine sulfate on the colon of cats and dogs. The mean duration of action of JB-340 was approximately equal to atropine sulfate (as determined by blockage of vagal stimuli). Atropine sulfate elicited a spasmogenic effect on the colon of the dog i n 60 per cent of the experiments. JB-340,0.5 mg./Kg.