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The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures

✍ Scribed by Douglas A. Horton; Gregory T. Bourne; Smythe Mark L. Smythe Mark L.


Publisher
John Wiley and Sons
Year
2003
Weight
56 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract **A privileged structure**: A library of tetrahydro‐1,4‐pyrazolo‐diazepin‐8(2__H__)‐ones was designed and synthesized to probe the privileged nature of the scaffold. The design strategy included mimicking the three‐dimensional conformations of β‐turn peptides. Screening against P2X~7~R,