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The Combination Very Low-Dose Naltrexone–Clonidine in the Management of Opioid Withdrawal

✍ Scribed by Wu, Li-Tzy; Patkar, Ashwin A.; Gorelick, David A.; Mannelli, Paolo; Peindl, Kathleen

Book ID
115443275
Publisher
Informa plc
Year
2012
Tongue
English
Weight
163 KB
Volume
38
Category
Article
ISSN
0095-2990

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## Abstract We previously described a decrease in withdrawal behaviors in opiate‐dependent rats that were chronically treated with very low doses of naltrexone in their drinking water. Attenuated expression of withdrawal behaviors correlated with decreased c‐Fos expression and intracellular signal