The combination of ursodeoxycholic acid and methotrexate for primary biliary cirrhosis is not better than ursodeoxycholic acid alone
✍ Scribed by Alvaro González-Koch; Javier Brahm; Cristina Antezana; Gladys Smok; Miguel A. Cumsille
- Book ID
- 118567709
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 785 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0168-8278
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This placebo-controlled, randomized, multicenter trial compared the effects of MTX plus UDCA to UDCA alone on the course of primary biliary cirrhosis (PBC). Two hundred and sixty five AMA positive patients without ascites, variceal bleeding, or encephalopathy; a serum bilirubin less than 3 mg/dL; se
Ursodeoxycholic acid (UDCA) and methotrexate (MTX) have both been proposed as treatments for patients with primary biliary cirrhosis (PBC). It has been suggested that a combination of the two drugs may offer advantages over either used separately. In this pilot study, we sought to evaluate the safet