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The Co-Expression of Activating and Inhibitory Leukocyte Immunoglobulin-Like Receptors in Rheumatoid Synovium

✍ Scribed by Nicodemus Tedla; Kathryn Gibson; H. Patrick McNeil; David Cosman; Luis Borges; Jonathan P. Arm

Book ID: 117022419
Publisher: American Society for Investigative Pathology
Year: 2002
Tongue: English
Weight: 731 KB
Volume: 160
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64861-4

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## Abstract ## Objective Serine proteinases activate the G protein–coupled receptor, proteinase‐activated receptor 2 (PAR‐2), via cleavage and exposure of a tethered ligand. PAR‐2 is known to exert proinflammatory actions in a murine model of arthritis, since PAR‐2–deficient mice exhibit strikingl