𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The clonal origin of cells contributing to successive phases of a cyclical immune response

✍ Scribed by J. M. Phillips; D. W. Dresser

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
704 KB
Volume
5
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A single injection of mice with a low dose of sheep red blood cells results in a cyclic appearance of antibody‐forming cells of the IgG classes. The peaks of the responses occur at the same time in the spleen and the thoracic lymph nodes. We have investigated the phenomenon with respect to IgG~2a~ response by using the isoelectric focusing overlay assay and have assumed that in the great majority of cases, after immunization with limiting amounts of antigen, an individual spectrotype represents a “clonal” product.

Enumeration of spectrotypes which arise only in the first peak and those which arise only in the second, suggests that the second peak of plaque‐forming cells can be accounted for on the basis of the stimulation of a second population of precursor cells. Several possible mechanisms whereby new antigen‐sensitive precursor cells can be turned on late in a primary response are discussed.

📜 SIMILAR VOLUMES

The inositol phosphate pathway as a medi
The inositol phosphate pathway as a mediator in the proliferative response of rat calvarial bone cells to cyclical biaxial mechanical strain
✍ Dr. Carl T. Brighton; Brian J. Sennett; James C. Farmer; Joseph P. Iannotti; Car 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 695 KB

## Abstract Isolated newborn rat calvarial bone cells grown in monolayer on polyurethane membranes in specially constructed culture chambers and subjected to a cyclical biaxial mechanical strain of 0.17% at a frequency of 1 Hz for 30 min demonstrated a 16% increase in DNA synthesis during the subse

Hyperglycemia regulates the glucose-tran
Hyperglycemia regulates the glucose-transport system of clonal choriocarcinoma cells in vitro. A potential molecular mechanism contributing to the adjunct effect of glucose in tumor therapy
✍ Tom Hahn; Sonja Barth; Wolfgang Hofmann; Olaf Reich; Ingrid Lang; Gernot Desoye 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 625 KB

Glucose is taken up by tumor cells via sodium-independent facilitated diffusion along a concentration gradient. To examine the regulation of this process by substrate concentration, we investigated the effect of hyperglycemia on the glucosetransport system of choriocarcinoma-derived JAR and JEG-3 ce

Nitric oxide contributes to the developm
Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction
✍ TanJanika Daniel; Michelle Alexander; William J. Hubbard; Irshad H. Chaudry; Mas 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB 👁 1 views

## Abstract Severe injury induces immune dysfunction resulting in increased susceptibility to opportunistic infections. Previous studies from our laboratory have demonstrated that post‐burn immunosuppression is mediated by nitric oxide (NO) due to the increased expression of macrophage inducible ni

Cellular basis for the immune response t
Cellular basis for the immune response to methylcholanthrene-induced tumors in mice. Heterogeneity of effector cells
✍ R. Kearney; A. Basten; D. S. Nelson 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 914 KB

## Abstract Immune resistance to methylcholanthrene‐induced tumors has two phases, an early specific and a late non‐specific phase. Both phases were found to be T‐cell‐dependent in vivo. Thus, adult thymectomized, irradiated, bone‐marrow‐protected mice bearing H‐1 tumor isografts showed impaired re