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The clonal and mutational evolution spectrum of primary triple-negative breast cancers

โœ Scribed by Shah, Sohrab P.; Roth, Andrew; Goya, Rodrigo; Oloumi, Arusha; Ha, Gavin; Zhao, Yongjun; Turashvili, Gulisa; Ding, Jiarui; Tse, Kane; Haffari, Gholamreza; Bashashati, Ali; Prentice, Leah M.; Khattra, Jaswinder; Burleigh, Angela; Yap, Damian; Bernard, Virginie; McPherson, Andrew; Shumansky, Karey; Crisan, Anamaria; Giuliany, Ryan; Heravi-Moussavi, Alireza; Rosner, Jamie; Lai, Daniel; Birol, Inanc; Varhol, Richard; Tam, Angela; Dhalla, Noreen; Zeng, Thomas; Ma, Kevin; Chan, Simon K.; Griffith, Malachi; Moradian, Annie; Cheng, S.-W. Grace; Morin, Gregg B.; Watson, Peter; Gelmon, Karen; Chia, Stephen; Chin, Suet-Feung; Curtis, Christina; Rueda, Oscar M.; Pharoah, Paul D.; Damaraju, Sambasivarao; Mackey, John; Hoon, Kelly; Harkins, Timothy; Tadigotla, Vasisht; Sigaroudinia, Mahvash; Gascard, Philippe; Tlsty, Thea; Costello, Joseph F.; Meyer, Irmtraud M.; Eaves, Connie J.; Wasserman, Wyeth W.; Jones, Steven; Huntsman, David; Hirst, Martin; Caldas, Carlos; Marra, Marco A.; Aparicio, Samuel


Book ID
111912195
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
682 KB
Volume
486
Category
Article
ISSN
0028-0836

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## Abstract Several models of evolution from primary cancers to metastases have been proposed; but the most widely accepted is the clonal evolution model proposed for colorectal cancer in which tumors develop by a process of linear clonal evolution driven by the accumulation of somatic genetic alte