𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The Clinical Utility Index as a Practical Multiattribute Approach to Drug Development Decisions

✍ Scribed by Poland, B; Hodge, FL; Khan, A; Clemen, RT; Wagner, JA; Dykstra, K; Krishna, R

Book ID
109845953
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
180 KB
Volume
86
Category
Article
ISSN
0009-9236

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Utility of a physiologically–based pharm
Utility of a physiologically–based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug–drug–disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice
✍ Joseph A. Grillo; Ping Zhao; Julie Bullock; Brian P. Booth; Min Lu; Kathy Robie- πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 535 KB

Background: Rivaroxaban is an oral Factor Xa inhibitor. The primary objective of this communication was to quantitatively predict changes in rivaroxaban exposure when individuals with varying degrees of renal impairment are co-administered with another drug that is both a P-gp and a moderate CYP3A4