𝔖 Bobbio Scriptorium
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The clinical spectrum of humidifier disease in synthetic fiber plants

✍ Scribed by Teake M. Pal; Jan G.R. de Monchy; Johan W. Groothoff; Doeke Post

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
126 KB
Volume
31
Category
Article
ISSN
0271-3586

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✦ Synopsis

In a synthetic fiber production site with recirculating cold water humidification systems and small-size-particle (.0.1Β΅ ,1Β΅) oil mist exposure, humidifier disease was diagnosed in several workers.

The patients could be divided into three groups illustrating the clinical spectrum of humidifier disease: humidifier fever (toxic inhalation fever) (12 patients); an asthma-like syndrome (8 patients); and allergic alveolitis (4 patients).

Natural challenge at the work place, monitored by parameters such as peak-flow, spirometry, blood leucocyte count, and body temperature, provided important diagnostic information. In patients with chronic allergic alveolitis, a gradual recovery during an exposure-free period indicated a work-related causation, more than changes during challenge in normal work.

In some patients, the fungus Sporothrix schenckii, hitherto unknown as a sensitizer, may have been at least one of the causative antigens. Measured levels of viable fungi (#100 CFU/m 3 ) and endotoxin (64 pg/m 3 ) in air samples were much lower than those at which health effects usually are reported. Small-size-particle oil mist exposure may have underestimated the exposure to microorganisms, but otherwise an adjuvant role to this type of co-exposure might also be postulated. In contrast to allergic alveolitis, the asthma-like syndrome appeared to be more common in patients with a history of atopy and of smoking. Am.

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