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The clinical significance of the spectrum of interactions of CAP+1 (A→C), a silent β-globin gene mutation, with other β-thalassemia mutations and globin gene modifiers in north Indians

✍ Scribed by Gurjeewan Garewal; Reena Das; Anshu Awasthi; Jasmina Ahluwalia; Ram Kumar Marwaha


Book ID
114794289
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
90 KB
Volume
79
Category
Article
ISSN
0902-4441

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✍ Youko Matsuno; Yasuhiro Yamashiro; Kunimitsu Yamamoto; Yukio Hattori; Kiyomi Yam 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 171 KB

Thalassemia is a heterozygous inherited disorder of [3globin synthesis lying cis to the defective [3-globin gene. Over 100 thalassemia mutations have been characterized in various ethnic groups and the same mutations have been observed in different ethnic groups. The haplotypes (HT) and [3-globin ge