The clinical patterns and molecular genetics of lissencephaly and subcortical band heterotopia
β Scribed by William B. Dobyns
- Book ID
- 109111578
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2010
- Tongue
- English
- Weight
- 247 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0013-9580
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Medicine is undergoing a quiet revolution. Molecular genetics is transforming clinical science and practice; the development of the Human Genome Project allows new methods of disease identification and of predicting disease patterns for individual patients. Knowledge of the human genome will deepen
Classical lissencephaly (LIS) and subcortical band heterotopia (SBH) are related cortical malformations secondary to abnormal migration of neurons during early brain development. Approximately 60% of patients with classical LIS, and one patient with atypical SBH have been found to have deletions or