The clinical impact of p16 status in fine-needle aspirates of cervical lymph node metastasis of head and neck squamous cell carcinomas
โ Scribed by Jens Jakscha, Inti Zlobec, Claudio Storck, Ellen C. Obermann, Luigi Tornillo, Luigi M. Terracciano, Claude A. Fischer
- Book ID
- 118784000
- Publisher
- Springer-Verlag
- Year
- 2012
- Tongue
- English
- Weight
- 179 KB
- Volume
- 270
- Category
- Article
- ISSN
- 0302-9530
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## Abstract ## Background. Because of the impact of nodal status on treatment and survival in squamous cell carcinoma of the head and neck, accurate staging of cervical lymph nodes is critical. This article explores the value of molecular analyses in the detection of cervical lymph node metastasis
Background. Prognosis of head and neck squamous cell carcinoma (HNSCC) is strongly associated with cervical lymph node metastasis. Cathepsin-D is a lysosomal protease expressed in all cells. Its role in extracellular matrix degradation is postulated to promote tumor invasion and metastasis. Increase