The cis-Specific Pictet−Spengler Reaction

✍ Scribed by Laura Alberch; Patrick D. Bailey; Paul D. Clingan; Timothy J. Mills; Richard A. Price; Robin G. Pritchard

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 123 KB
• Volume: 2004
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200400017

✦ Synopsis

Abstract

The Pictet−Spengler reaction of tryptophan allyl ester with aryl aldehydes generates cis‐tetrahydro‐β‐carbolines with complete stereo‐control and with complete retention of optical integrity, when the reaction is carried out under kinetically controlled conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)