The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis
โ Scribed by Aron Gyuris; Diana J. Donovan; Kimberly A. Seymour; Lindsay A. Lovasco; Nathaniel R. Smilowitz; Anthony L.P. Halperin; Jan E. Klysik; Richard N. Freiman
- Book ID
- 116272534
- Publisher
- Elsevier
- Year
- 2009
- Tongue
- English
- Weight
- 630 KB
- Volume
- 1789
- Category
- Article
- ISSN
- 1874-9399
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## Abstract **BACKGROUND:** Closure of the cranial neural tube during embryogenesis is a crucial process in development of the brain. Failure of this event results in the severe neural tube defect (NTD) exencephaly, the developmental forerunner of anencephaly. **METHODS:** The requirement for methy
## Abstract ## BACKGROUND Neural tube closure is a critical embryological process that requires the coordination of many molecular and cellular events. Only recently has the molecular basis of the cell movements that drive neural tube closure begun to be elucidated. This has been accomplished in p