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The cholinergic system, sigma-1 receptors and cognition

โœ Scribed by Aren van Waarde; Nisha K. Ramakrishnan; Anna A. Rybczynska; Philip H. Elsinga; Kiichi Ishiwata; Ingrid M. Nijholt; Paul G.M. Luiten; Rudi A. Dierckx


Book ID
116285716
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
531 KB
Volume
221
Category
Article
ISSN
0166-4328

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## Abstract Cognitive impairment is a primary feature of patients with major depressive disorder (MDD) and is characterised by stressโ€induced neural atrophy. Via alphaโ€adrenergic, antiโ€cholinergic and antiโ€histaminic activities, several antidepressants can cause significant counterโ€therapeutic cogn