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The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of ratin vitroandin vivo

✍ Scribed by Barsanjit Mazumder; Shyamali Mukherjee; Parimal C. Sen

Publisher: Springer
Year: 1990
Tongue: English
Weight: 513 KB
Volume: 95
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00219525

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✦ Synopsis

Chlorpromazine, an antipsychotic drug, is found to inhibit Na+,K(+)-ATPase activity in rat brain microsomal membranes in vitro in concentration and time dependent manner but some inconsistency is observed when the effect was studied with respect to different temperatures. Various ligands and/or substrate affect the inhibition by chlorpromazine in different ways. The in vivo study with this drug shows that the activities of Na+,K(+)-ATPase, Ca2(+)-ATPase and acetylcholinesterase in the microsomal membranes of different organs are inhibit with increases in concentration or lengths of time of treatment and then levels off.

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