The chemistry of vicinal tricarbonyl compounds. Short syntheses of eudistomins T, I and M

✍ Scribed by Harry H. Wasserman; Terence A. Kelly

• Book ID: 104244554
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 198 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)93439-2

✦ Synopsis

The formation of three novel 1,2,3-tricarbonyl compounds and their use in the total syntheses of eudistomins T, I and M is described.

In earlier work we have shown that vicinal tricarbonyl compounds may be used effectively for the formation of products in the isoquinoline,l indole, and erythrinas alkaloid series. In this communication we show how these derivatives may be used in short, efficient syntheses of eudistomins T (l), I (2) and M (3), members of a family of marine alkaloids possessing antiviral activity.