✍ Scribed by Shoichiro Ozaki
No coin nor oath required. For personal study only.
In the past, many 1,2-oxazetidine derivatives have been reported (2), but no 1,3-oxazetidine has been reported yet.
The author obtained 2-oxo-3-phenyl-l,j-oxazetidine (I) by the reaction of phenyl isocyanate with tetraoxane. This is the first example of a four membered ring compound having oxygen and nitrogen at the 1 and 3 positions.
📜 SIMILAR VOLUMES
## Abstract The cyclization of phenacyl anthranilate has been studied with the aim to develop the synthesis of 2‐(2′‐aminophenyl)‐4‐phenyloxazole. However, a different course of the reaction than expected was observed. 2‐Phenyl‐2‐hydroxymethyl‐4‐oxo‐1,2,3,4‐tetrahydroquinazoline (**3a**) was formed
## Abstract magnified image A facile approach was developed on assembly of the 2‐pyridone nucleus by ferric chloride promoted [3+3] cycloaddition in propionic acid. The tandem process involves cyclization of Michael adduct followed by aromatization. Thus, different substituted 1,2‐dihydro‐2‐oxo‐3‐