Penicillin transformations : I. Conversi
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Ödön K.J. Kovacs; Bertil Ekström; Berndt Sjöberg
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Article
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1969
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Elsevier Science
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French
⚖ 213 KB
In a recent paper Wolfe and Lee (1) reported the epimerization at C-6 of methyl 6-phthalimidopsnicillanate (I) on treatment with basic reagents such as sodium hydride, potassium t-butoxide, or triethylamine. They suggested a reaction mechanism (I~II+III) involving a $-elimination with rupture of the