The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist

✍ Scribed by Glenn R Carlson; Tarlochan S Dhadialla; Ricky Hunter; Richard K Jansson; Christine S Jany; Zev Lidert; Richard A Slawecki

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 95 KB
• Volume: 57
• Category: Article
• ISSN: 1526-498X
• DOI: 10.1002/1526-4998(200102)57:2<115::aid-ps245>3.0.co;2-a

✦ Synopsis

Methoxyfenozide [N-tert-butyl-N '-(3-methoxy-o-toluoyl)-3,5-xylohydrazide; RH-2485] is the newest diacylhydrazine insecticide to reach the marketplace. It binds with very high af®nity to the ecdysone receptor complex (EcR:USP) in lepidopteran insects [K d = 0.5 nM (Plodia)], where it functions as a potent agonist, or mimic, of the insect molting hormone, 20-hydroxyecdysone (20E). Methoxyfenozide exhibits high insecticidal ef®cacy against a wide range of important caterpillar pests, including many members of the family Pyralidae, Pieridae, Tortricidae and Noctuidae. It is most effective when ingested by the target caterpillar, but it also has some topical and ovicidal properties. It is modestly root systemic, but not signi®cantly leaf-systemic. Evidence collected to date indicates that methoxyfenozide has an excellent margin of safety to non-target organisms, including a wide range of non-target and bene®cial insects.