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The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population

✍ Scribed by Zdenek Kleibl; Ondrej Havranek; Ivona Hlavata; Jan Novotny; Jan Sevcik; Petr Pohlreich; Pavel Soucek

Book ID
116429819
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
257 KB
Volume
45
Category
Article
ISSN
0959-8049

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## Abstract __MKK4__ (mitogen‐activated protein kinase kinase 4, NM\_003010.2), which belongs to the mitogen‐activated protein kinase pathways, possesses functions in tumorigenesis. We hypothesized the genetic variants in __MKK4__ gene may alter its functions and thus cancer risk. In current hospit