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The characteristics of the inhibition of serum cholinesterase by metoclopramide

✍ Scribed by S. G. Graham; A. W. A. Crossley

Publisher
Springer
Year
1995
Tongue
English
Weight
393 KB
Volume
48-48
Category
Article
ISSN
0031-6970

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✦ Synopsis

The inhibition of serum cholinesterase by metoclopramide has been previously characterised in vitro at high dilution of the enzyme. We examined the effect of varying enzyme dilution over a range of 1000 fold dilution, and assay temperature at 25Β°C and 37Β°C on the fractional inhibition of enzyme activity by metoclopramide. Neither enzyme concentration nor reaction temperature affected this fractional inhibition. Concentrations of metoclopramide producing 50% inhibition of enzyme activity were in the range 1.0-1.9 Γ— 10 -6 M. Lineweaver-Burk analysis of the enzyme reaction suggests that the pattern of this inhibition is competitive.

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