Doppler Global Velocimetry (DGV) is a whole-ÿeld measurement technique which has attracted signiÿcant interest from the uid-ow research community since its introduction in 1991. Practical implementations of the methodology have focused on two principal laser light sources: the argon ion laser, applied to steady state or slowly varying ows; and the pulsed neodymium YAG laser for the measurement of instantaneous velocity ÿelds. However, the emphasis in the published literature has been very much on research using the argon laser. This paper reports the application of a Q-switched, injection-seeded neodymium YAG laser to the proven Oxford DGV system, and the use of this combination in a short duration unsteady high-speed ow. The pertinent characteristics of the apparatus are described, and the impact of these on the integrity of the resulting velocity measurements is presented. Adaptations to the commercial laser system that make it suitable for application to the measurement of transient high-speed ows are described. Finally, the application of this system to a short duration unsteady ow is described. This application is based on the ow found in a new type of transdermal drug delivery device, where particles of the drug material are projected at high speed through the skin. Whole-ÿeld velocities are recorded, and values as high as 800 m=s are evident.