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The channels model of nuclear matrix structure

โœ Scribed by Sergey V. Razin; Irina I. Gromova

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
885 KB
Volume
17
Category
Article
ISSN
0265-9247

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โœฆ Synopsis

The specificity of eukaryotic DNA organization into loops fixed to the nuclear matrixkhromosomal scaffold has been studied for more than fifteen years. The results and conclusions of different authors remain, however, controversial. Recently, we have elaborated a new approach to the study of chromosomal DNA loops. Instead of characterizing loop basements (nuclear matrix DNA), we have concentrated our efforts on the characterization of individual loops after their excision by DNA topoisomerase Il-mediated DNA cleavage at matrix attachment sites. In this review the results of applying this mapping approach are compared with the results and conclusions from studies of nuclear matrix DNA. An attempt is also made to reconsider all data about the specificity of DNA interactions with the nuclear matrix and to suggest a model of spatial organization of the eukaryotic genome which

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