A novel suicide inhibitor strategy for a
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C. C. Wang
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Article
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1991
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John Wiley and Sons
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English
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DL-a-Difluoromethylornithine (DFMO), a suicide inhibitor of eukaryotic ornithine decarboxylase (ODC), has therapeutic activities against African trypanosomiasis. The K, value of DFMO for ODC of Trypanosoma brucei is somewhat higher than that for mouse ODC. The therapeutic efficacy of DFMO cannot the