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The cGMP-binding, cGMP-specific phosphodiesterase (PDE5): intestinal cell expression, regulation and role in fluid secretion

โœ Scribed by Shailaja Sopory; Tanvir Kaur; Sandhya S. Visweswariah


Book ID
113527587
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
497 KB
Volume
16
Category
Article
ISSN
0898-6568

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Stable toxin (ST) peptides are the causative agents for a severe form of watery diarrhea. These peptides bind to a membrane-associated form of guanylyl cyclase, guanylyl cyclase C. The result is an accumulation of cyclic guanosine monophosphate (cGMP) in the intestinal cell, regulating protein kinas