The Cerebellum and its Disorders

✍ Scribed by Mario-Ubaldo Manto (editor), Massimo Pandolfo (editor)

• Publisher: Cambridge University Press
• Year: 2002
• Tongue: English
• Leaves: 612
• Edition: 1
• Category: Library

✦ Synopsis

Recent years have seen major advances in the understanding of motor and nonmotor operations of the cerebellum, including its role in cognition, and important discoveries in the genetics of the cerebellar ataxias. This comprehensive text on the cerebellum and its disorders ranges from embryology and basic neuroanatomy to a thorough survey of the sporadic and hereditary disorders of the cerebellum. Models of cerebellar function and clinical-pathophysiological correlations are thoroughly covered, and there is an extensive and authoritative review of recent advances in the genetics of cerebellar diseases. The chapters are written by the leading international authorities on the cerebellum.

✦ Table of Contents

Cover......Page 1
Frontmatter......Page 2
Contents......Page 6
List of contributors......Page 10
Preface......Page 18
Acknowledgments......Page 20
Foreword by Sid Gilman......Page 22
PART I - INTRODUCTION......Page 24
1 - Embryology of the cerebellum......Page 26
2 - Neuroanatomy of the cerebellum......Page 29
3 - High-resolution cerebellar anatomy......Page 53
4 - Neurotransmitters in the cerebellum......Page 61
5 - Structure and function of the cerebellum......Page 72
PART II - THEORIES OF CEREBELLAR CONTROL......Page 90
6 - Models of cerebellar function......Page 92
PART III - CLINICAL SIGNS AND PATHOPHYSIOLOGICAL CORRELATIONS......Page 118
7 - Clinical signs of cerebellar disorders......Page 120
8 - Pathophysiology of clinical cerebellar signs......Page 144
9 - The role of the cerebellum in affect and psychosis......Page 159
PART IV - SPORADIC DISEASES......Page 182
10 - Congenital malformations of the cerebellum and posterior fossa......Page 184
11 - Multiple system atrophy and idiopathic late-onset cerebellar ataxia......Page 201
12 - Corticobasal degeneration......Page 221
13 - Cerebellar stroke......Page 225
14 - Immune diseases......Page 251
15 - Infectious diseases: radiology and treatment of cerebellar abscesses......Page 260
16 - Other infectious diseases......Page 271
17 - Cerebellar disorders in cancer......Page 288
18 - Posterior fossa trauma......Page 311
19 - Thyroid hormone and cerebellar development......Page 328
20 - Endocrine disorders: clinical aspects......Page 339
PART V - TOXIC AGENTS......Page 348
21 - Alcohol toxicity in the cerebellum: fundamental aspects......Page 350
22 - Alcohol toxicity in the cerebellum: clinical aspects......Page 359
23 - Other cerebellotoxic agents......Page 365
PART VI - ADVANCES IN GRAFTS......Page 390
24 - Cerebellar grafts......Page 392
PART VII - NEUROPATHOLOGY......Page 408
25 - Neuropathology of the inherited ataxias......Page 410
PART VIII - DOMINANTLY INHERITED PROGRESSIVE ATAXIAS......Page 430
26 - Spinocerebellar ataxia type 1......Page 432
27 - Spinocerebellar ataxia type 2......Page 442
28 - Spinocerebellar ataxia type 3......Page 451
29 - Spinocerebellar ataxia type 4......Page 463
30 - Spinocerebellar ataxia type 5......Page 468
31 - Spinocerebellar ataxia type 6......Page 474
32 - Autosomal dominant cerebellar ataxia with progressive pigmentary macular dystrophy......Page 482
33 - Spinocerebellar ataxia type 8......Page 492
34 - Dentatorubral-pallidoluysian atrophy......Page 504
35 - Molecular mechanisms of triplet repeat expansions in ataxias......Page 514
PART IX - RECESSIVE ATAXIAS......Page 526
36 - Friedreich's ataxia......Page 528
37 - Early-onset inherited ataxias......Page 542
38 - Ataxia telangiectasia and variants......Page 554
39 - Ataxia in mitochondrial disorders......Page 571
40 - Episodic ataxias as ion channel diseases......Page 585
Index......Page 596