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The Central Region of Gadd45 Is Required for Its Interaction with p21/WAF1

✍ Scribed by Hongcheng Zhao; Shunqian Jin; Michael J Antinore; Feng-Di T Lung; Feiyue Fan; Patricia Blanck; Peter Roller; Albert J Fornace Jr.; Qimin Zhan

Book ID
115603704
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
204 KB
Volume
258
Category
Article
ISSN
0014-4827

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## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s