The central nervous system environment controls effector CD4+ T cell cytokine profile in experimental allergic encephalomyelitis

T cells are the main cell type expressin

T cells are the main cell type expressing B7-1 and B7-2 in the central nervous system during acute, relapsing and chronic experimental autoimmune encephalomyelitis

✍ Anne H. Cross; Jeri A. Lyons; Manuel San; Richard M. Keeling; Grace Ku; Michael 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB 👁 1 views

T cell co-stimulation through the CD28 receptor on T cells is critical to the induction of experimental autoimmune encephalomyelitis (EAE). In this study, expression of the co-stimulatory ligands B7-1 (CD80) and B7-2 (CD86), as well as the receptors CD28 and CTLA-4, were quantitated in central nervo