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The cellular delivery of antisense oligonucleotides and ribozymes

โœ Scribed by Marcus D Hughes; Majad Hussain; Qamar Nawaz; Pakeeza Sayyed; Saghir Akhtar

Book ID
114383209
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
136 KB
Volume
6
Category
Article
ISSN
1359-6446

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Treatment of systemic disease with phosphorothioate antisense oligonucleotides (PS ASOs) has been accomplished using local or parenteral routes of administration to date. This report describes, for the first time, the effective oral delivery of a second generation oligonucleotide where significant m