The controlled extension of neurites is essential not only for nervous system development, but also for effective nerve regeneration after injury. This process is critically dependent on microtubule assembly since axons fail to elongate in the presence of drugs which disrupt normal assembly dynamics
The cell's microtubules: Growth dynamics, ordering of dipoles and modes of energy propagation
✍ Scribed by J.A. Tuszyński; D. Sept; B. Trpisová
- Book ID
- 103897763
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 927 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0378-4754
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✦ Synopsis
The cytoskeleton consists of networks of protein polymers which structurally and dynamically organize interiors of living cells. Microtubules are the best characterized and perhaps most fundamental filamentous subcellular structures known to date. Microtubules exhibit a fascinating array of self-organization phenomena which are very sensitive to various laboratory conditions. In this paper we discuss the main physical features of microtubules focusing our attention on their dynamics of assembly (disassembly), nonlinear modes suitable for energy transfer along the protofilaments and the possible dipolar phases which we predict.
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