✦ LIBER ✦

The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells

✍ Scribed by Lala R. Chaudhary; Keith A. Hruska

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 167 KB
Volume: 81
Category: Article
ISSN: 0730-2312
DOI: 10.1002/1097-4644(20010501)81:2<304::aid-jcb1045>3.0.co;2-u

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Extracellular-signal regulated kinase si

Extracellular-signal regulated kinase signaling pathway mediates downregulation of type I procollagen gene expression by FGF-2, PDGF-BB, and okadaic acid in osteoblastic cells

✍ Lala R. Chaudhary; Louis V. Avioli 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

Although basic fibroblast growth factor (FGF-2) had been shown to inhibit type I collagen gene expression in osteoblast, its inhibitory mechanism is unknown. In the present study, we investigated the underlying mechanisms by which growth factors downregulate type I collagen gene expression. Treatmen

Signaling through FGF receptor-2 is requ

Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation

✍ Claudia M. Garcia; Kai Yu; Haotian Zhao; Ruth Ashery-Padan; David M. Ornitz; Mic 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 637 KB

Increased sensitivity to the platelet-de

Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation

✍ Tiziana Servidei; Anna Riccardi; Maurizio Sanguinetti; Carlo Dominici; Riccardo 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 377 KB

## Abstract The platelet‐derived growth factor receptor (PDGFR) is a tyrosine kinase, implicated in the development and progression of different tumors, including gliomas. Chemoresistance is a common feature of malignant gliomas. Since receptor tyrosine kinases contribute to chemoresistance in tumo

Specific inhibitor of FGF receptor signa

Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells

✍ Rashmi Bansal; Suma Magge; Susan Winkler 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB 👁 1 views

## Abstract Multiple studies have shown that migration, proliferation, and differentiation of oligodendrocyte (OL) lineage cells are influenced by fibroblast growth factor‐2 (FGF‐2) signaling through its receptors (FGFR) FGFR‐1, FGFR‐2, and FGFR‐3. We report the effectiveness and specificity of a u

Oncostatin M–induced CCL2 transcription

Oncostatin M–induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: An implication for the pathogenesis of arthritis

✍ Sang-Heng Kok; Chi-Yuan Hong; Mark Yen-Ping Kuo; Chih-Chiang Wang; Kuo-Liang Hou 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 2 views

## Abstract ## Objective To examine the roles of STATs 1 and 3 in CCL2 production in human osteoblastic cells and their influences on arthritis development. ## Methods The expression of CCL2 in primary human osteoblasts and U2OS human osteoblastic cells was examined by Northern blotting and enzy

Extracellular signal-regulated kinase ac

Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by In Vivo liver injury in the rat

✍ Fabio Marra; Maria Cristina Arrighi; Marilena Fazi; Alessandra Caligiuri; Massim 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 1 views

Upon liver injury, hepatic stellate cells (HSC) show increased proliferation, motility, and extracellular matrix (ECM) production. The extracellular signal-regulated kinases (ERK) control different functions in a cell-specific manner. In this study, we evaluated the role of ERK activation in culture