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The cell surface expression level of the human interleukin-5 receptor α subunit determines the agonistic/antagonistic balance of the human interleukin-5 E13Q mutein

✍ Scribed by Xaveer Van Ostade; José Van Der Heyden; Annick Verhee; Joël Vandekerckhove; Jan Tavernier


Book ID
114429686
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
687 KB
Volume
259
Category
Article
ISSN
1432-1327

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## Abstract The interaction of biotinylated human interleukin 5 ([BT]hIL5) with immobilized receptor was measured with a real‐time biosensor, and these results were used as a basis for configuring as ELSIA for screening antagonists of hIL5‐receptor binding. The recombinant proteins used, hIL5 and s