β Scribed by James L. Maller (auth.), Valerie W. Hu (eds.)
No coin nor oath required. For personal study only.
Interest in the cell cycle has grown explosively in recent years as a result of the identification of key cell cycle regulators and their substrates. Aside from enhancing our understanding of normal cellular growth controls, this new knowledge has also becn valuable in elucidating mechanisms of growth deregulation which occur in diseased states, such as cancer and, in some instances, viral or parasitic infections. The Thirteenth Washington International Spring Symposium was organized with the intention of bringing together scientists working on different aspects of the cell cycle. Scientific topics presented ranged from molecular regulators and effectors to mitosisΒ specific changes in cell architecture to the role of the cell cycle in development and disease. The goal of this gathering was to help formulate a more comprehensive and integrated picture of events driving and being driven by the cell cycle, as well as to evaluate the possibilities for clinical application of this knowledge. This symposium, held in Washington, D.C. from May 10-14, 1993, was attended by more than 400 scientists from 20 countries, including many of the scientific leaders in this field. This volume contains most of the papers presented at the seven plenary sessions in addition to selected contributions from a total of nine special oral and poster sessions.
Front Matter....Pages i-xi
Front Matter....Pages 1-1
Protein Phosphorylation and the Regulation of Key Events in Oocyte and Egg Cell Cycles....Pages 3-15
Control of G1 Progression by Mammalian D-Type Cyclins....Pages 17-23
Phosphorylation in the Regulation of Protein Phosphatases....Pages 25-32
Positive and Negative Regulation of Cell Cycle Progression by Serine/Threonine Protein Phosphatases....Pages 33-40
Effects of Phosphatase Inhibitors on Mammalian p34 cdc2 Kinase Activities....Pages 41-49
The Meiotic Role of twine , A Drosophila Homologue of cdc25 ....Pages 51-57
Front Matter....Pages 59-59
Extracellular Signal-Regulated Protein Kinases (ERKS) 1, 2, and 3....Pages 61-66
Cell Cycle Traverse and Growth Arrest Control in Senescent Human Fibroblasts....Pages 67-78
Cellular Senescence and the Cell Cycle....Pages 79-89
Cell Cycle Targets of Viral Oncoproteins....Pages 91-97
A GTPase Cycle Coupled to the Cell Cycle....Pages 99-110
Sphingolipids Metabolites: A New Class of Second Messengers in the Regulation of Cell Growth....Pages 111-119
Front Matter....Pages 121-121
Histone Gene Transcription During the Cell Cycle....Pages 123-125
G1-S Regulatory Promoter Elements and their Interacting Transcription Factors....Pages 127-139
Regulation of Thymidylate Synthase Gene Expression in Growth-Stimulated Cells....Pages 141-147
The Role of the Transcription Factor E2F in the Growth Regulation of DHFR....Pages 149-154
Activation of the Heat Shock Transcription Factor During G 1 ....Pages 155-161
DNA Damage and Cell Cycle Regulation in S. Cerevisiae ....Pages 163-166
Preferential Repair of Cisplatin Adducts in the Human DHFR Gene During G 1 Phase Assayed with T4 DNA Polymerase....Pages 167-171
Front Matter....Pages 173-173
Direct Inhibition of p107 WEE1 by the Nim 1/CDR 1 Kinase....Pages 175-184
Front Matter....Pages 173-173
A Human Phosphotyrosine Phosphatase Associated with M Phase-Promoting Factor....Pages 185-188
The Localisation of Human Cyclins and CDKS in the Cell Cycle....Pages 189-195
Regulation of Nuclear Envelope Assembly and Disassembly by ARF and other GTP-Binding Proteins....Pages 197-202
Possible Role of the Multi Catalytic Proteinase (Proteasome) in Regulating of the Cell Cycle....Pages 203-209
Cytostellin: A Nuclear Protein that Redistributes to Peripheral Cytoskeletal Locations During Mitosis and G1....Pages 211-221
Evidence for M-Phase-Specific Modification of a Gap Junction Protein....Pages 223-228
Analysis of Centrosome Replication Events in Mammalian Cells....Pages 229-235
Requirements for Microtubule Polymerization and a Calcium Surge for the Metaphase-to-Interphase Transition in Mature Mouse Oocytes....Pages 237-243
Front Matter....Pages 245-245
Mos Proto-Oncogene and Cell Cycle Regulation....Pages 247-249
Altered Regulation of Cell Cycle Genes and Proteins in Senescent Human Diploid Fibroblasts....Pages 251-262
Cell Proliferation as a Biomarker of Age and Development....Pages 263-269
Heat Shock Genes and Cell Cycle Regulation During Early Mammalian Development....Pages 271-281
Expression of G1 Cyclins During Early Development of Zebrafish Embryos....Pages 283-289
Apoptosis: Definition, Roles and Regulation....Pages 291-299
Front Matter....Pages 301-301
Molecules of Deregulated Cell Cycle Control in Cancer....Pages 303-309
The Two Amino Terminal Transforming Functions of the SV40 Large T-Antigen are Required to Overcome P53 Mediated Growth Arrest....Pages 311-317
Down Regulation of Candidate Tumor Suppressor Genes in Breast Cancer....Pages 319-322
Expression and Regulation of Cyclin Genes in Breast Cancer Cells....Pages 323-329
Genotoxin-Induced Apoptosis: Implications for Carcinogenesis....Pages 331-340
Monitoring and Repair of DNA Damage During G 2 in Relation To Carcinogenesis....Pages 341-346
Front Matter....Pages 301-301
Cell Cycle Regulation in Normal Versus Leukemic T Cells....Pages 347-357
Cells Undergoing HIV Envelope-Mediated Programmed Degeneration Accumulate in G2/M Phase....Pages 359-366
Front Matter....Pages 367-367
The Involvement of the Cell Cycle in Apoptosis....Pages 369-378
Cell Cycle Regulation and the Chemosensitivity of Cancer Cells....Pages 379-388
Multiple Cell Cycle Checkpoint Override and its Potential for Binary Tumor Therapy....Pages 389-396
Radiation Induced G2 Delay and Mitotic Cyclin Expression....Pages 397-403
Cyclin B Degradation as a Target of Antiproliferative Drug Action....Pages 405-410
Clinical Relevance of DNA Ploidy and Cell Cycle Phases in Transitional Cell Carcinoma of the Renal Pelvis and Ureter: A Study by Means of Static DNA-Cytophotometry....Pages 411-419
Back Matter....Pages 421-430
Biochemistry, general; Animal Anatomy / Morphology / Histology; Plant Sciences
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