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The Cell Cycle Cdc25A Tyrosine Phosphatase Is Activated in Degenerating Postmitotic Neurons in Alzheimer's Disease

✍ Scribed by Xiao-Ling Ding; Jacob Husseman; Andrei Tomashevski; David Nochlin; Lee-Way Jin; Inez Vincent

Book ID: 117022402
Publisher: American Society for Investigative Pathology
Year: 2000
Tongue: English
Weight: 799 KB
Volume: 157
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64837-7

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## Abstract Adult neurons are generally accepted to be in a quiescent, nonproliferative state. However, it is becoming increasingly apparent that, in Alzheimer's disease (AD), alterations in cell cycle machinery, suggesting an attempt to reenter cell cycle, relate temporally and topographically to