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The CDK inhibitor p21 WAF1/Cip 1 is induced through a p300-dependent mechanism during NGF-mediated neuronal differentiation of PC12 cells

โœ Scribed by Billon, Nathalie; Grunsven, Leo A.; Rudkin, Brian B.


Book ID
122262506
Publisher
Portland Press
Year
1996
Tongue
English
Weight
182 KB
Volume
88
Category
Article
ISSN
0248-4900

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We investigated the possible involvement of HTLV-1 Tax in the transcriptional activation of p21/Waf1/Cip1 (hereafter p21), a potent inhibitor of cyclin-dependent kinases and cell growth. Tax transfection resulted in enhanced expression of p21 protein in T and fibroblastoid cells. Similarly, Tax-expr